Dr. Hettiarachchy's research lab investigates basic and applied alternate food proteins and peptides with an integrated approach to value addition in nutraceuticals, natural antioxidants, and antimicrobials from Arkansas-grown crops, and industry co-products. In particular, protein research involves extraction, separation, purification, characterization, and using state-of-the art instrumentation and technologies, and conducting functional and functionality properties, as well as nutrient interactions, and mechanisms. Biotechnology is used in preparing bioactive peptides and researched for anti-cancer, anti-obesity, and anti-Alzheimer’s activities with mechanisms and genomics in human cell lines. Extracts derived from plant and industry-co-products including proteins and peptides are investigated for antioxidants, and antimicrobials activities with an integrated approach to meet current and future evolving research demand. Research also involves creating commercially feasible technologies of focused research aimed at conducting collaborative basic and applied research with food companies.
- Identify and develop traditional and non-traditional food protein sources and conduct basic and applied research for value added uses.
- Develop nutraceuticals and functional compounds for value addition
- Isolate and purify bioactive peptides and conduct proteomic and mechanistic research and investigate their activities in health and in specific diseases.
- Develop natural antimicrobial and antioxidant extracts for enhanced activities
- Develop novel and innovative wholesome food products with an understanding from molecules focusing on alternate proteins for health and wellness
FDSC 4713: Product Innovation for the Food Scientist
FDSC 6323: Nutraceuticals and Functional Foods
FDSC 6333: Food Protein Chemistry and Functionality
Postgraduate Diploma Certificate in Human Nutrition (ICMR, Hyderabad, India)
Ph.D.- University of Hull, Yorkshire, England (Biochemistry, Molecular)
M.Sc.- University of Edinburgh Medical School, Edinburgh, Scotland (Biochemistry, Enzymology)
B.Sc.- University of Madras, Chennai, Tamil Nadu, India (Chemistry)
*Denotes corresponding author (2010-present)
John S. Edwards, *Navam S. Hettiarachchy, T.K.S Kumar, Franck Carbonereo, Eizabeth M. Martin,, and Mourad Bennamara. 2020. Physicochemical properties of soy protein hydrolysate and its formulation and stability with encapsulated probiotic under in vitro gastrointestinal environment, Journal of food science. https://doi.org/10.1111/1750-3841.15399
Ledoux, M. L., *Hettiarachchy, N., Yu, X., Howard, L., & Lee, S. O. 2020. Penetration of glyphosate into the food supply and the incidental impact on the honey supply and bees. Food Control, 109, 106859.
Jiang H, *Hettiararchchy NS, Horax R. 2019. Quality and estimated glycemic profile of baked protein-enriched corn chips. J. Food Sci Technol. 56(6):2855-2862.doi: 10.1007/s13197-019-03717-6.
Brnawi WI, *Hettiarachchy NS, Horax R, Kumar-Phillips G, Ricke S. 2019. Antimicrobial activity of leaf and bark cinnamon essential oils against Listeria monocytogenes and Salmonella typhimurium in broth system and on celery. J Food Process Preserv. 2019; e13888. https://doi.org/10.1111/jfpp.13888
Bruce, R.M., Atungulu, G.G., Hettiarachchy, N.S., Horax, R. 2019. Functional properties of endosperm protein from size-fractionated broken rice kernels generated after milling of parboiled and nonparboiled rice. Cereal Chemistry. 96:590–604.
Massey, L., *Hettiarachchy, N.S., Horax, R., Rayaprolu, S., Kumar-Phillips, G., Martin, E.M., Ricke, S. 2018. Efficacy of organic acid electrostatic spray for decontaminating Salmonella on cantaloupe cubes and cherry tomatoes. Journal of Food Processing and Preservation. 2018; 42:e13748. https://doi.org/10.1111/jfpp.13748.
Al-Doury, M. K. W., *Hettiarachchy, N. S., Horax, R. 2018. Rice Endosperm and Bran Proteins. A review. J American Oil Chemists’ Society 95: 943–956
Maetens, E., *Hettiarachchy, N., Dewettinck, K., Horax, R., Moens, K. 2018. Reductions of anti-nutritional factors by ultraviolet and infrared light treatments in snack chips prepared from germinated soybeans. LWT-Food Science and Technology. 90:513-518.
Brnawi, W.I., *Hettiarachchy, N.S., Horax, R., Kumar-Phillips, G., Seo, H., Marcy, J. 2018. Comparisons of cinnamon essential oils from leaf and bark with respect to antimicrobial activity and sensory acceptability in strawberry shake. Journal of Food Science 83:475-480.
Jiang, H., *Hettiararchchy, N.S., Horax, R. 2018. Physical properties and estimated glycemic index of protein-enriched sorghum based chips. Journal of Food Science and Technology. 55(3): 891–898
Maetens, E., *Hettiarachchy, N., Dewettinck, K., Horax, R., Moens, K, Moseley D.O. 2017. Physicochemical and nutritional properties of a healthy snack chip developed from germinated soybeans. LWT-Food Science and Technology. 84:505-510.
Rayaprolu, S.J., *Hettiarachchy, N.S., Horax, R., Kumar-Phillips, G., Liyanage, R., Lay, J., and Chen, P. 2017. Purification and characterization of a peptide from soybean with cancer cell proliferation inhibition. Journal of Food Biochemistry. (Published online: 21 March 2017). 2017;00:e12374. https://doi.org/10.1111/jfbc.12374
Rayaprolu, S.J., *Hettiarachchy, N.S., Horax, R., Phillips, G.K, Mahendran, M., Chen, P. 2017. Soybean peptide fractions inhibit human blood, breast and prostate cancer cell proliferation. Journal of Food Science and Technology 54(1): 38–44. IF: 1.241
Abutheraa, R., *Hettiarachchy, N., Kumar-Phillips, G., Horax, G., Chen, P., Morawicki, R., and Kwon Y.M. 2017. Antimicrobial activities of phenolic extracts derived from seed coats of selected soybean varieties. Journal of Food Science. 82(3):731-737.
Horax, R., Vallecios, M.S., *Hettiarachchy, N., Osorio, L.F., and Chen, P. 2017. Solubility, functional properties, ACE-I inhibitory and DPPH scavenging activities of Alcalase hydrolyzed soy protein hydrolysates. International Journal of Food Science and Technology. 52(1): 196–204. DOI: 10.1111/ijfs.13267. IF: 1.504.
Nguyen Q, *Hettiarachchy, N., Rayaprolu, S., Seo, H., Horax, R., Chen, P., and Thallapuranam, S.K.K. 2016. Protein-rich beverage developed using non-GM soybean (R08-4004) and evaluated for sensory acceptance and shelf-life. Journal of Food Science and Technology. 53(8): 3271–3281. DOI: 10.1007/s13197-016-2302-0.
Graves, A.M., *Hettiarachchy N, Rayaprolu S, Li R, Horax, R., Seo, H. 2016. Bioactivity of a rice bran derived peptide and its sensory evaluation and storage stability in orange juice. Journal of Food Science. 81(4): H1010-H1015
Nguyen Q, *Hettiarachchy, N., Rayaprolu, S., Jayanthi, S., Thallapuranam, S.K.K. and Chen, P. 2016. Physicochemical properties and Angiotensin-I converting enzyme inhibitory activity of protein hydrolysates from a non-genetically modified soy cultivar. Journal of American Oil Chemist’s Society. 93(4):595-606
Almasoud, A., *Hettiarachchy, N., Rayaprolu, S., Babu, D., Kwon, Y. M., and Mauromoustakos, A. 2016. Inhibitory effects of lactic and malic organic acids on autoinducer type 2 (AI-2) quorum sensing of Escherichia coli O157:H7 and Salmonella Typhimurium. LWT-Food Science and Technology, 66: 560–564.
Khairallah, M. G., *Hettiarachchy, N., and Rayaprolu, S. 2016. Stability and quality of a bioactive peptide fraction incorporated orange juice. LWT-Food Science and Technology. 66: 523-529.
Ganesh, V., *Hettiarachchy, N.S. 2016. A review: Supplementation of foods with essential fatty acids – Can it turn a breeze without further ado? Critical Reviews in Food Science and Nutrition. 56(9):1417-1427. doi: 10.1080/10408398.2013.765383.
Almasoud, A., *Hettiarachchy, N., Rayaprolu, S., Horax, R., Eswaranandam, S. 2015. Electrostatic spraying of organic acids on biofilms formed by E. coli O157:H7 and Salmonella Typhimurium on fresh produce. Food Research International, 78 (2015) 27–33.
Rayaprolu, S., *Hettiarachchy, N., Aldoury, M., Cho, S., Moseley, D., and Chen, P. 2015. Physical and textural attributes of freeze-dried genetically modified and non-genetically modified soy beans. Journal of Food and Nutritional Sciences, 3(3): 119-125.
Rayaprolu, S., *Hettiarachchy, N., Horax, R., Satchithanandam, E., Chen, P., and Mauromoustakos, A. 2015. Amino acid composition of 44 soybean lines and ACE-I inhibition activities of peptide fractions prepared from selected lines. Journal of American Oil Chemists’ Society, 92(7): 1023-1033.
Li, R., *Hettiarachchy, N., Rayaprolu, R., Davis, M., Eswaranandam, S., Jha, A., and Chen, P. 2015. Improved functional properties of glycosylated soy protein isolate using D-glucose and xanthan gum. Journal of Food Science and Technology, 52(9): 6067-6072.
Li, R., *Hettiarachchy, N., Rayaprolu, S., Eswaranandam, S., Howe, B., Davis, M., and Jha, A. 2014. Phenolics and antioxidant activity of saskatoon berry (Amelanchier alnifolia) pomace extract. Journal of Medicinal Foods, 17(3): 384-392.
Singh, M., Jha, A., Kumar, A., Hettiarachchy, N., Rai, A., and Sharma, D. 2014. Influence of the solvents on the extraction of major phenolic compounds (punicalagin, ellagic acid and gallic acid) and their antioxidant activities in pomegranate aril. Journal of Food Science and Technology, 51(9): 2070-2077.
Lassissi, T.A., *Hettiarachchy, N., Rayaprolu, S.J., Theivendran, S., and Brye, K.R. 2014. Physio-chemical and sensory properties of protein-fortified extruded breakfast cereal/snack formulated to combat protein malnutrition in developing countries. Journal of Food Processing and Technology, 5(8): 359. DOI: 10.4172/2157-7110.1000359
Webber, A., *Hettiarachchy, N.S., Webber, D.M., Sivarooban, T., and Horax, R. 2014. Heat-stabilized defatted rice bran (HDRB) as an alternative growth medium for Saccharomyces cerevisiae. Journal of Food and Nutrition, 1: 1-6.
Tortayeva, D.D., *Hettiarachchy, N., Horax, R., and Eswaranandam, S. 2014. Effects of germination on nutrient composition of long grain rice & physico-chemical and functional properties of long grain rice protein. Journal of Food and Nutrition, 1: 1-9.
Lassissi, T.A., *Hettiarachchy, N.S., Rayaprolu, S.J., Kannan, A., and Davis, M. 2014. Functional properties and angiotensin converting enzyme-1 inhibitory activity of soy whey proteins and fractions. Food Research International Journal, 64: 598-602.
Alessa, F., *Hettiarachchy, N., Rayaprolu, S.J., Ravichandran, M., Benamara, M., Greathouse, D. and Singh, S. 2014. Stability of nano encapsulated rice bran derived bioactive pentapeptide in apple juice. Journal of Food Processing and Technology, 5(8): 356. DOI: 10.4172/2157-7110.1000356.
Li, R., *Hettiarachchy, N., and Mahadevan, M. 2014. Rice bran derived pentapeptide-induced apoptosis in human breast cancer cell models (MCF-7 and MDA-MB-231). International Journal of Biomedical Research, 5(10): 599-605.
Webber, D., *Hettiarachchy, N., Li, R., Horax, R., and Thievendran, S. 2014. Phenolic profile and antioxidant activity of extracts prepared from fermented heat-stabilized defatted rice bran. Journal of Food Science, 79(11): H2383-2391.
Li, R., *Hettiarachchy, N., Mahadevan, M. 2014. Apoptotic pathways in human breast cancer cell models (MCF-7 and MDA-MB-231) induced by rice bran derived pentapeptide. International Journal of Medical Research and Health Sciences, 4(5): 13-21.
Horax, R., *Hettiarachchy, N., and Chen, P. 2014. Characteristics and functionality enhancement by glycosylation of bitter melon (Momordica charantia) seed protein. Journal of Food Science, 79(11): C2215-2221.
Rayaprolu, S J, *Hettiarachchy NS, Chen P., Kannan, A., and Mauromostakos, A. 2013. Peptides Derived from High Oleic Acid Soybean Meals Inhibit Colon, Liver and Lung Cancer Cell Growth. Food Research International 50, pp. 282-288.
Divya, D, *Hettiarachchy, N., Ganesh, V., Kannan, A., Rayaprolu, S. 2013. Phenolic Extracts from Leaves of Bitter Melon (Momordica charantia) with Antioxidant Properties Journal of Agricultural Science and Application. 2, (1): 28-34.
Malviya S., Jha A. A., Hettiarachchy, N. 2013. Antioxidant and antibacterial potential of pomegranate peel extracts. J Food Sci Technol. Published online DOI 10.1007/s13197-013-0956-4.
Crandall, P. Han-Seok, S., O'Bryan, C., Meullenet, J.F., Hettiarachchy, N.S., McCain, A., Ranhotra, G. 2013. Physicochemical analysis of wheat flour fortified with vitamin A and three types of iron source and sensory analysis of bread using these flours. J Sci. Food Agric. 93(9): 2299–2307.
Massey, LM, *Hettiarachchy, NS, Martin, EM, and Ricke, SC. 2013. Electrostatic Spray of Food-Grade Organic Acids and Plant Extract to Reduce Escherichia coli O157:H7 on Fresh-cut Cantaloupe Cubes. J. Food Safety 33(1): 71-78.
Perumalla, A. V. S., *Hettiarachchy, N. S., Over, K., Ricke, S. C., Slavik, M. F., Gbur, E., Davis, B. and Acosta, S. 2013. Effect of partial replacement of potassium lactate and sodium diacetate by natural green tea and grape seed extracts and post-packaging thermal treatment on the growth of Listeria monocytogenes in hotdog model system. International Journal of Food Science & Technology 48: 918–926.
Ganesh, V., *Hettiarachchy, N.S. 2012. Nutriproteomics: A promising tool to link diet and diseases in nutritional research. Biochimica et Biophysica Acta. 1824(10): 1107–1117.
Ganesh, V., *Hettiarachchy, N.S. Griffis, C. L. Martin, E. M. and Ricke S. C. 2012. Electrostatic Spraying of Food-grade Organic and Inorganic Acids and Plant Extracts to Decontaminate Escherichia coli O157:H7 on Spinach and iceberg Lettuce. J Food Science. 77(7): M391–M396.
Kannan, A., *Hettiarachchy, N.S., Mahadevan, M. 2012. Peptides derived from rice bran protect cells from obesity and Alzheimer’s disease. Inter. J Biomed. Res. 3(03): 131-135.
Perumalla, A.V.S., *Hettiarachchy, N.S., Over, K.F., Ricke, S.C., Gbur, E.E., Zhang, J., Davis B. 2012. Effect of potassium lactate and sodium diacetate combination to inhibit Listeria monocytogenes in low and high fat chicken and turkey hotdog model systems. The Open Food Science Journal, 6, 16-23.
Ravichandran, M., *Hettiarachchy, N.S., Ganesh, V., Ricke, S.C., Singh. S. 2011. Enhancement of antimicrobial activities of naturally occurring phenolic compounds by nanoscale delivery against Listeria monocytogenes, Escherichia coli O157:H7 and Salmonella Typhimurium in broth and chicken meat system. J Food Safety. 31(4): 462-471.
Zhang M, *Hettiarachchy N, Horax, R. Kannan, A., Praisoody, A., Muhundan, A., and Mallangi, CR. 2011. Selected phytochemicals and antioxidant activities of Hibiscus sabdariffa, Centella asiatica, and Moringa oleifera and Murraya koenigii leaves. J Med Plant Res. 5(30), 6672-6680.
Rababah, T., Over, K., *Hettiarachchy, N.S., Horax, R., Eswaranandam, S., Davis, B., Dickson, J. and Niebuhr, S. 2010. Infusion of Plant Extracts during Processing to Preserve Quality Attributes of Irradiated Chicken Breasts over 9 months storage at -20 °C. Journal of Food Processing and Preservation, 34:287-307.
Horax, R., *Hettiarachchy, N.S., Over, K., Chen, and P. Gbur. E. 2010. Extraction, fractionation and characterization of bitter melon seed proteins. J Agric Food Chemistry, 58: 1892–1897.
Horax R, *Hettiarachchy N, Chen P. 2010. Extraction, quantification, and antioxidant activities of Phenolics from Pericarp and Seeds of Bitter Melons (Momordica charantia) Harvested at Three Maturity Stages (Immature, Mature, and Ripe). J Agric Food Chem. 58(7):4428-33.
Horax R, *Hettiarachchy, N, Kannan A, and Pengyin Chen. 2010. Proximate composition, amino acid and mineral contents of Mormordica charantia L. pericarp and seeds at different maturity stages. Food Chem 122(4): 1111-15.
Kannan, A, *Hettiarachchy, N, Lay, JO, Liyanage, R. 2010. Human Cancer Cell Proliferation Inhibition by a Pentapeptide Isolated and Characterized From Rice Bran.Peptides J 31(9): 1629-1634.
Horax R, *Navam Hettiarachchy, Kannan A and Pengyin Chen. 2010. Protein extraction optimization, characterization, and functionalities of protein isolate from bitter melon (Momordica charantia) seed. Food Chem. 124(2): 545-550.
Ganesh, V., *Hettiarachchy, N.S., Ravichandran, M., Johnson, M. G., Griffis, C.L. Martin, E.M., Meullenet, J.F. Ricke. S.C., 2010 Electrostatic Sprays of Food-grade Acids and Plant Extracts are More Effective than Conventional Sprays to Decontaminate Salmonella Typhimurium on Spinach. J Food Sci. 75(9): M574-M579.
Gadang V, Gilbert W, Hettiararchchy N, Horax R, Katwa L, Devareddy L. 2010. Dietary bitter melon seed increases peroxisome proliferator-activated receptor-? gene expression in adipose tissue, down-regulates the nuclear factor-?b expression, and alleviates the symptoms associated with the metabolic syndrome. J Med Food. 14(1-2):86-93.
Over, K. F. *Hettiarachchy N. S. Perumalla, A. V. S. Johnson, M. G. Meullenet, J-F. Dickson, J. S. Holtzbauer, M. J. Niebuhr, S. E. Davis. B. 2010. Antilisterial Activity and Consumer Acceptance of Grape Seed and Green Tea Extracts and Tartaric Acid Vacuum-Infused into Chicken Breast Meat. J Food Sci. 75(7):M455-61.
Resource Faculty to Asian Productivity Organization (APO), Japan
University Professor, University of Arkansas, Department of Food Science
Professor, University of Arkansas, Department of Food Science
Associate Professor, University of Arkansas, Department of Food Science
Associate Professor and Director of Food Science, North Dakota State University, Department of Cereal Science and Food Technology
Senior Research Scientist and Project Leader, Nestle R & D, New Milford, Connecticut
Visiting Professor, University of Illinois at Urbana-Champaign, Department of Food Science
Post graduate Certificate in Human Nutrition (ICMR, Hyderabad, India)
Lecturer/Senior Lecturer, Biochemistry, Peredeniya Medical School, Sri Lanka
Elected Fellow of the International Academy of Food Science and Technology (IAFoST)
Elected as a Director of Phi Tau Sigma-IFT
National Academy of Inventors
Spitze Land Grant University Faculty Award for Excellence. United States Patent Award Plaque "Bioactive pentapeptide from rice bran and use thereof"
American Association of Food Scientists for Indian Subcontinent (AAFSIS) President (2012-2014)
Proteins and Co-Products Division Chair, AOCS
International Education Award, Sponsored Student Programs, University of Arkansas Graduate School
John W. White Outstanding Research Award, Bumpers College, University of Arkansas
IFT College Bowl Team coach, Distinguished /Outstanding Achievement recognition, Department
John White Outstanding Teacher Award, Bumpers College, University of Arkansas
Teaching Award of Merit, North American Colleges and Teachers of Agriculture
International Scientist of the Year award. The International Biographical Centre of Cambridge, England.
Outstanding Teaching Award, Department of Food Science, University of Arkansas
2005 and 2003
Outstanding Mentor, Undergraduate Honors Class University of Arkansas
Institute of Food Technologists (IFT) Fellow, Institute of Food Technologists
Outstanding Mentor, University of Arkansas
2003, 2000, 1999, 1998
Outstanding Teaching Award, Department of Food Science
Archer Daniels’ Midland Award for best paper in Chemistry and Nutrition
Outstanding Teaching Award, Gamma Sigma Delta (6), College of Agriculture, University of Arkansas